Heatmap of the 426 differentially expressed genes by indirect difference analysis. The inner circles are microcystic LMs and the outer circles correspond to macrocystic LMs. Gene names discussed in the text are colored in red for macrocystic, blue for microcystic, and green for members of the PI3K/AKT pathway. Links join genes on the same hallmark pathway and they are colored as follows: MYC—blue, epithelial–mesenchymal transition—red, hipoxia—purple, fatty acid methabolism—brown, oxidative phosphorylation—green, adipogenesis—orange. A color version of this figure is available in the online article at www.liebertpub.com/lrb