FIG. 7.

Epigenetic clocks purport to identify epigenetic profiles that are predictive of future life expectancy. The figure shows the isometric (dashed) line, where the epigenetic age is identical to the chronological age, and findings from two mouse populations. Wang et al. (107) examined wild-type and rapamycin-treated mice. In wild-type mice (solid blue line), the epigenetic clock matches chronological age early on, but at late ages, it tends to underestimate age. Treatment with rapamycin (solid red line) significantly extends lifespan and makes mice appear younger than their chronological age across the lifespan.