Table 4.

Comparisons between premixed human insulins vs premixed insulin analogues vs insulin co-formulation in patients with T2DM

Modified from [54]

Parameter	Premixed human insulin	Premixed insulin analogue	Insulin co-formulation
PPG control	+	+++	+++
FPG control	++	++	+++
HbA1c control	+	++	++
Less hypoglycemia	+	++	+++
Mealtime flexibility	+	+++	+++
Weight gain	+	++	++

PPG postprandial glucose, FPG fasting plasma glucose, HbA1c glycated hemoglobin A1c