Table 3.

Factors affecting choice of initial therapy in restless legs symptoms

RLS symptomatology
Associated insomnia  Painful restless legs  Doubtful diagnosis of RLS vs DPN  Severe symptoms  Refractory symptoms	α2δ ligand (gabapentin enacarbil) α2δ ligand α2δ ligand Dopaminergic agonist (pramipexole, rotigotine) Oxycodone, naloxone
Comorbid conditions
Overweight  Metabolic syndrome  Depression  Generalized anxiety disorder  Nephropathy  Osteoporosis	Dopaminergic agonist Dopaminergic agonist Dopaminergic agonist α2δ ligand/consider iron Ropinirole α2δ ligand