Table 3.
The effects of the three regimens on overall glycemic control
| PHI70/30 | LM25 | LM50 | P 1 | P 2 | P 3 | |
|---|---|---|---|---|---|---|
| HbA1c (%) | 7.8 ± 1.4 | 7.6 ± 1.1 | 7.5 ± 1.1 | 0.203 | 0.091 | 0.682 |
| GA (%) | 19.6 ± 3.9 | 19.6 ± 3.8 | 19.2 ± 3.9 | 0.936 | 0.515 | 0.572 |
| Mean blood glucose (mmol/L) during the whole day | 9.5 ± 2.5 | 9.6 ± 2.0 | 9.3 ± 2.6 | 0.768 | 0.687 | 0.500 |
| Mean blood glucose (mmol/L) during the daytime (6:00 a.m.–22:00 p.m.) | 10.6 ± 2.6 | 10.7 ± 2.5 | 10.2 ± 2.7 | 0.795 | 0.462 | 0.352 |
| Mean blood glucose (mmol/L) during the night (0:00–6:00 a.m. and 22:00–24:00 p.m.) | 8.4 ± 3.2 | 8.6 ± 2.7 | 8.3 ± 2.8 | 0.788 | 0.842 | 0.528 |
Data are given as mean ± SD or as median (5–95% percentile range)
PHI70/30 premixed human insulin 70/30, LM25 insulin lispro mix 25, LM50 insulin lispro mix 50, HbA1c glycated hemoglobin, GA glycated albumin, PPGE postprandial glucose excursion, LAGE large amplitude of glucose excursion, MAGE mean amplitude of glucose excursion
P1: PHI 70/30 vs. LM25, P2: PHI70/30 vs. LM50, P3: LM25 vs. LM50