Table 4.
The effects of the three regimens on glycemic excursions
| PHI70/30 | LM25 | LM50 | P 1 | P 2 | P 3 | |
|---|---|---|---|---|---|---|
| Blood glucose at breakfast (mmol/L) | ||||||
| 1 h before meal | 8.4 ± 2.9 | 8.4 ± 2.4 | 8.5 ± 2.5 | 0.971 | 0.849 | 0.828 |
| 1 h after meal | 9.1 ± 2.8 | 9.4 ± 2.5 | 9.4 ± 2.5 | 0.587 | 0.572 | 0.979 |
| 2 h after meal | 10.4 ± 3.2 | 10.0 ± 2.7 | 9.5 ± 2.8 | 0.445 | 0.042 | 0.384 |
| PPGE | 3.8 ± 3.0 | 2.4 ± 2.6 | 1.3 ± 2.5 | 0.005 | 0.000 | 0.046 |
| Blood glucose at lunch (mmol/L) | ||||||
| 1 h before meal | 9.5 ± 3.4 | 9.2 ± 3.0 | 8.2 ± 3.3 | 0.689 | 0.022 | 0.068 |
| 1 h after meal | 9.5 ± 2.7 | 9.3 ± 2.8 | 9.0 ± 2.7 | 0.744 | 0.313 | 0.509 |
| 2 h after meal | 10.1 ± 2.8 | 9.9 ± 2.9 | 10.0 ± 2.9 | 0.814 | 0.924 | 0.937 |
| PPGE | 2.8 ± 3.0 | 3.0 ± 2.9 | 3.3 ± 3.1 | 0.668 | 0.336 | 0.572 |
| Blood glucose at dinner (mmol/L) | ||||||
| 1 h before meal | 9.6 ± 3.5 | 9.9 ± 3.4 | 10.1 ± 3.2 | 0.592 | 0.378 | 0.737 |
| 1 h after meal | 9.7 ± 3.0 | 10.1 ± 3.2 | 10.0 ± 2.8 | 0.428 | 0.552 | 0.848 |
| 2 h after meal | 10.0 ± 3.2 | 10.3 ± 3.0 | 9.8 ± 2.8 | 0.574 | 0.686 | 0.383 |
| PPGE | 3.3 ± 3.4 | 2.8 ± 2.4 | 1.5 ± 2.8 | 0.325 | 0.012 | 0.036 |
| LAGE (mmol/L) | 9.3 ± 3.5 | 8.9 ± 3.1 | 8.9 ± 3.8 | 0.480 | 0.509 | 0.967 |
| MAGE (mmol/L) | 5.7 ± 2.7 | 5.6 ± 2.8 | 5.5 ± 2.8 | 0.872 | 0.715 | 0.849 |
Data are given as mean ± SD or as median (5–95% percentile range)
PHI70/30 premixed human insulin 70/30, LM25 insulin lispro mix 25, LM50 insulin lispro mix 50, HbA1c glycated hemoglobin, GA glycated albumin, PPGE postprandial glucose excursion, LAGE large amplitude of glucose excursion, MAGE mean amplitude of glucose excursion
P1: PHI 70/30 vs. LM25, P2: PHI70/30 vs. LM50, P3: LM25 vs. LM50