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Solution structure of α-catenin dimer. (A) A SAXS curve of an α-catenin dimer model generated from SASSIE Monte Carlo simulation (red line) with best fit to the dimer fraction of SEC-SAXS data (black square) is shown, χ2 < 1.21. (B) χ2 vs. Rg plots of the fits of SASSIE generated models to the dimer SEC-SAXS data are shown. Two rounds of simulations are performed to minimize the χ2. (C) A representative α-catenin dimer structural model with minimized χ2 is shown.
