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. 2018 Aug 22;38(34):7529–7540. doi: 10.1523/JNEUROSCI.3032-17.2018

Figure 6.

Figure 6.

Headache triggers depress TRPV1/ChR2 synapses. A, D, G, Representative single experiments showing depression of optically-evoked EPSCs following 10 min bath application of NTG (100 μm; A), SNP (150 μM; D) and PACAP-38 (10 μm; G). B, E, H, Summary of normalized data showing depression induced by NTG (B), SNP (E), and PACAP-38 (H). C, F, I, Non-normalized data showing oEPSCs at baseline compared with 15–20 min following bath application of NTG (C; 73 ± 8%; paired t test: ***p = 0.0009, n = 11), SNP (F; 70 ± 8%; paired t test: **p = 0.007, n = 11), and PACAP-38 (I; 75 ± 9%; paired t test: *p < 0.03, n = 10). Insets, EPSCs before (black trace, control), and 20 min after drug application (green trace). Scale bars: 5 ms, 25 pA. Insets are averages of six oEPSCs.