Table 3.
Univariable cox regression analyses of survival.
| Variable | HR (95% CI) | |
|---|---|---|
| OS (Stage I-IIIA) | DFS (Stage I) | |
| Age, per year | 1.02 (0.99, 1.04) | 1.02 (0.98, 1.06) |
| Sex (F/M) | 0.42 (0.10, 1.72) | 1.16 (0.28, 4.86) |
| Race (Nonwhite/White) | 1.09 (0.63, 1.88) | 1.17 (0.45, 3.03) |
| Symptomatic (N/Y) | 0.88 (0.56, 1.40) | 1.67 (0.76, 3.67) |
| ECOG PS (≥ 2/<2) | 1.21 (0.70, 2.11) | 1.68 (0.81, 3.50) |
| Family history (N/Y) | 1.29 (0.62, 2.69) | 0.21 (0.03, 1.51) |
| Each pack year | 1.01 (1.00, 1.02) | 1.02 (1.01, 1.03) |
| DM (N/Y) | 0.94 (0.54, 1.66) | 1.47 (0.60, 3.49) |
| CKD (N/Y) | 0.50 (0.25, 1.01) | 0.63 (0.22, 1.80) |
| COPD (N/Y) | 0.74 (0.44, 1.22) | 0.65 (0.29, 1.43) |
| Any respiratory comorbidity (N/Y) | 0.65 (0.37, 1.14) | 0.40 (0.14, 1.13) |
| CAD (N/Y) | 0.99 (0.60, 1.64) | 2.5 (1.05, 6.12) |
| HF (N/Y) | 0.70 (0.36, 1.37) | 1.62 (0.50, 5.28) |
| Any CVD comorbidity (N/Y) | 0.89 (0.51, 1.54) | 1.46 (0.64, 3.35) |
| Other cancer history (N/Y) | 0.82 (0.51, 1.33) | 0.74 (0.37, 1.47) |
| Alcohol dependence (N/Y) | 0.76 (0.40, 1.44) | 0.77 (0.30, 1.99) |
| Comorbidity score | ||
| SCS, per point | 1.08 (1.01, 1.15) | 1.03 (0.93, 1.14) |
| SCS > 9 (N/Y) | 0.64 (0.40, 1.00) | 0.88 (0.45, 1.70) |
| Any psychiatric illness (N/Y) | 0.79 (0.49, 1.28) | 0.86 (0.43, 1.71) |
| Pulmonary function (per % pred) | ||
| FEV1 | 0.99 (0.98, 1.00) | 0.99 (0.98, 1.01) |
| TLC | 1.00 (0.98, 1.01) | 1.01 (0.99, 1.04) |
| DLCO | 0.99 (0.97, 1.00) | 0.98 (0.97, 1.00) |
| Ventilatory defect (N/Y) | ||
| Obstructive | 0.85 (0.53, 1.36) | 0.71 (0.34, 1.49) |
| Restrictive | 0.92 (0.37, 2.28) | 1.30 (0.18, 9.54) |
| DLCO limitation | 0.67 (0.42, 1.07) | 0.54 (0.27, 1.07) |
| Tumor size, per cm | 1.21 (1.09, 1.34) | 1.41 (1.05, 1.89) |
| SCLC (N/Y) | 0.87 (0.35, 2.16) | 0.50 (0.12, 2.11) |
| Clinical stagea | 1.82 (1.15, 2.88) | 0.43 (0.22, 0.85) |
| Treatment category | ||
| Surgical resection | 0.32 (0.17, 0.59) | ref |
| SBRT/XRT | 0.57 (0.34, 0.97) | 2.07 (1.02, 4.24) |
| Chemoradiation | ref | N/A |
| Time to treatment | ||
| TTT, per day | 1.00 (0.99, 1.00) | 1.00 (0.99, 1.01) |
| Most TT (N/Y) | 0.95 (0.60, 1.52) | 1.11 (0.54, 2.26) |
| Least TT (N/Y) | 0.54 (0.29, 1.01) | 0.86 (0.39, 1.90) |
CAD = coronary artery disease; CI = confidence interval; CKD = chronic kidney disease; COPD = chronic obstructive pulmonary disease; CTB = chest tumor board; CVD = cardiovascular disease; DFS = disease-free survival; DLCO = diffusion capacity of the lung for carbon monoxide; DM = diabetes mellitus; ECOG PS = Eastern Cooperative Oncology Group Performance Status; F = female; FEV1 = forced expiratory volume in 1 s; HF = heart failure; HR = hazard ratio; M = male; OS = overall survival; SBRT = stereotactic body radiotherapy; SCLC = small cell lung cancer; SCS = simplified comorbidity score; TLC = total lung capacity; TT = timely treatment; TTT = time to treatment; XRT = radiotherapy.
Bolded variables: statistically significant, p < 0.05.
Categorized as stage I (N/Y) for stage I-IIIA patients, or stage IA/IB for stage I patients.