. Author manuscript; available in PMC: 2019 Feb 1.

Published in final edited form as: Respir Med. 2018 Jul 17;141:172–179. doi: 10.1016/j.rmed.2018.07.005

Table 4A.

Multivariable cox regression analyses^* of overall survival in stage I-IIIA patients.

Model 1^†
Variable	HR (95% CI)	P-value
DL_CO, per 10% predicted	0.86 (0.76, 0.98)	0.02
Treatment category^**
Surgery	0.32 (0.16, 0.62)	0.003
SBRT/XRT	0.40 (0.21, 0.76)	0.02
Chemoradiation	ref	Ref
TTT, per day	1.00 (0.99, 1.01)	0.56
Model 2^‡
Variable	HR (95% CI)	P-value
Each pack year	1.01 (1.00, 1.02)	0.11
DL_CO, per 10% predicted	0.86 (0.75, 0.98)	0.02
Treatment category^**
Surgery	0.36 (0.18, 0.69)	0.006
SBRT/XRT	0.39 (0.21, 0.73)	0.009
Chemoradiation	ref	ref
Least TT (N/Y)	0.53 (0.27, 1.01)	0.054

Stepwise backward selection including baseline characteristics with p < 0.15: smoking history (pack year), SCS, DLCO % predicted, stage I/II-IIIA disease, treatment category.

^**

P-values corrected for 3 pairwise comparisons.

^†

Overall model P < 0.001; no significant interaction between DL_CO and treatment category (p=0.95).

^‡

Overall model P < 0.001; no significant interaction between DL_CO and pack year (p=0.37) or timely treatment and treatment category (p=0.73).