Table 3.
IC50 values for compounds 2–6 against erythrocytic stage of two P. falciparum strains.
| Compd | IC50 [μm] | Compd | IC50 [μm] | ||
|---|---|---|---|---|---|
| Pf3D7 | Pf3Dd2 | Pf3D7 | Pf3Dd2 | ||
| 2 a | 100.0±11.0 | 74.1±5.3 | 4 d | >27.7 | >27.7 |
| 2 b | 2.9±0.2 | 7.2±1.9 | 4 e | 6.1±0.1 | >27.7 |
| 2 c | 81.1±3.4 | 80.1±31.0 | 5 a | 15.8±1.7 | 27.1±0.8 |
| 2 d | 6.6±0.2 | 50.4±4.6 | 5 b | 0.4±0.1 | 1.9±0.8 |
| 2 e | 27.1±0.6 | 25.0±2.8 | 5 c | 3.7±1.3 | 13.6±0.2 |
| 3 a | >111 | >111 | 5 d | 0.6±0.2 | 1.2±0.04 |
| 3 b | >111 | >111 | 6 a | >111 | 94.4±8.6 |
| 3 c | >111 | >111 | 6 b | 8.3±0.9 | 14.8±0.1 |
| 3 d | >111 | >111 | 6 c | >111 | >111 |
| 3 e | >111 | >111 | 6 d | >111 | >111 |
| 4 a | >55 | 50.0±5.0 | 6 e | >25 | >27.7 |
| 4 b | >27.7 | >27.7 | PQ[a] | 1.5±0.02 | 4.3±1.5 |
| 4 c | 39.5±15.5 | 35.5±1.2 | CQ[b] | 1.6×10−3 | 0.265±0.003 |
[a] Primaquine. [b] Chloroquine.