Figure 2.
Overall growth of teratomas in long‐term hyperthermal regimes (mean ± SEM). A/A 0 ‐ explant area/explant area at the beginning of culture. A, Growth of explants in the serum‐supplemented medium in the hyperthermal regime at 40.5°C from the first day (CEM43°C 630 min) was as in controls and that was significantly higher than in the hyperthermal regime at 40.5°C from the second day (CEM43°C 585 min). Note that growth of teratomas at 40.5°C from the second day with the addition of antibody against HSP70 (CEM43°C 585 min) was the lowest and significantly different in comparison with controls and the two other regimes at 40.5°C. ANOVA: **P < .001; ***P < .0001; B, growth of teratomas in the chemically defined medium with transferrin as the only protein was significantly lower during the first week at 40.5°C (CEM43°C = 630 min) in comparison with controls cultivated at 37°C. Student's t test: ***P < .0001