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Yin and Yang of p53. (A) The p53/white adipose tissue/Cancer nexus. (B) The adipose tissue microenvironment contributes significantly to malignancy through tumor microenvironment communication. Regardless of the p53 status of the tumor cell, stimulation of oncogenic signaling pathways by p53-dependent adipokine production from the white adipose tissue in the microenvironment may facilitate tumor propagation.
