Table 2.
Comparison of the concentration of total choline (tCho), apparent diffusion coefficient (ADC) and volume in both pathological and clinical responders (R) and non-responders (NR) at pre-therapy (Tp0) and after I (Tp1), II (Tp2), and III (Tp3) NACT.
| Time point | tCho (mM/Kg) | ADC (10−3 mm2/s) | Volume (cm3) | |||
|---|---|---|---|---|---|---|
| pR | pNR | pR | pNR | pR | pNR | |
| PATHOLOGICAL RESPONSE | ||||||
| Tp0 | 5.75 ± 3.44*#@$ (n = 24) | 4.29 ± 2.15*#@$ (n = 18) | 1.00 ± 0.16*#@ (n = 24) | 1.05 ± 0.15#@ (n = 18) | 74.15 ± 61.65#@$ (n = 24) | 116.36 ± 93.92@$ (n = 18) |
| Tp1 | 3.00 ± 2.21* (n = 22) | 3.09 ± 1.46* (n = 12) | 1.12 ± 0.16* (n = 22) | 1.10 ± 0.13 (n = 13) | 53.40 ± 45.56 (n = 22) | 80.06 ± 55.14 (n = 13) |
| Tp2 | 2.28 ± 2.08# (n = 17) | 2.90 ± 1.52# (n = 8) | 1.19 ± 0.14# (n = 17) | 1.20 ± 0.20# (n = 8) | 29.32 ± 22.12# (n = 17) | 51.42 ± 42.96 (n = 8) |
| Tp3 | 1.46 ± 2.12@ (n = 24) | 2.63 ± 1.93@ (n = 17) | 1.35 ± 0.20@ (n = 24) | 1.19 ± 0.20@ (n = 17) | 21.61 ± 18.59@ (n = 24) | 53.77 ± 50.27@ (n = 17) |
| cR | cNR | cR | cNR | cR | cNR | |
| CLINICAL RESPONSE | ||||||
| Tp0 | 5.47 ± 2.94*#@ (n = 26) | 4.56 ± 3.15 (n = 16) | 0.96 ± 0.13*#@$ (n = 26) | 1.12 ± 0.16$ (n = 16) | 90.90 ± 82.47#@ (n = 26) | 94.42 ± 75.51 (n = 16) |
| Tp1 | 2.99 ± 1.70* (n = 25) | 3.14 ± 2.66 (n = 9) | 1.14 ± 0.14* (n = 25) | 1.04 ± 0.14 (n = 10) | 60.08 ± 50.52 (n = 25) | 71.37 ± 51.35 (n = 10) |
| Tp2 | 2.04 ± 1.32# (n = 20) | 4.23 ± 2.96 (n = 5) | 1.21 ± 0.13# (n = 20) | 1.07 ± 0.06 (n = 4) | 28.35 ± 21.33# (n = 20) | 68.56 ± 45.54 (n = 5) |
| Tp3 | 1.02 ± 1.40@ (n = 26) | 3.55 ± 2.18 (n = 15) | 1.40 ± 0.15@ (n = 26) | 1.08 ± 0.13 (n = 15) | 16.12 ± 15.69@ (n = 26) | 67.57 ± 44.1 (n = 15) |
*
Denotes significance between values at pre therapy and I NACT.
#
Denotes significance between values at pre therapy and II NACT.
@
Dnotes significance between values at pre therapy and III NACT.
$
Denotes significance between values at pre therapy.