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. 2018 Aug 14;9:1685. doi: 10.3389/fimmu.2018.01685

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Copyright © 2018 Di Cristofaro, Karlmark, Kanaan, Azzouz, El Haddad, Hubert, Farge-Bancel, Granel, Harlé, Hachulla, Pardoux, Roudier, Picard and Lambert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Concentration of soluble HLA-G (sHLA-G) per mL of plasma according to different human leukocyte antigen (HLA)-G genotypes. The eight polymorphisms tested (−725, −716, −201, −56, Ins/Del, +3,142, +3,187, and +3,196) are represented with their three possible genotypes (i.e., GG, GT, and TT for −716 SNP) except for −725 SNP for which six genotypes exist: CC, CT, GC, TT, GG, and GT but the last three were not represented on the graph as only few women had these genotypes; sHLA-G concentration values are represented for each genotypes in green (on the left side) for healthy women and in red (on the right side) for women with SSc. A red square is surrounding alleles or genotypes having been described in most studies with high HLA-G production. Means and SDs are given for each scatter plot by black bars. P values are calculated by Mann–Whitney tests.