Table 1.
Receptors that signal via CARMA3.
| (A) G protein-coupled receptors (GPCRs) in solid tumors | |||
|---|---|---|---|
| Receptor | Ligand | Tumor-type | Reference |
| AGTR1 | Angiotensin II | Breast cancer | Ekambaram et al. (50) |
| CXCR4 | CXCL12/SDF-1 | Oral squamous cell carcinoma | Rehman and Wang (47) |
| LPAR | LPA | Ovarian cancer | Mahanivong et al. (51) |
| (B) GPCRs in non-malignant cells | |||
| Receptor | Ligand | Disease/cellular system | Reference |
| AGTR1 | Angiotensin II | Vascular inflammation and atherogenesis | McAllister-Lucas et al. (52) |
| Hepatocytes | McAllister-Lucas et al. (44) | ||
| CXCR2 | CXCL8/IL8 | Endothelial cells | Martin et al. (46) |
| ETAR | Endothelin-1 | Mouse embryonic fibroblasts (MEFs) | Grabiner et al. (53) |
| LPAR | LPA | Asthma | Medoff et al. (54) and Causton et al. (55) |
| MEFs | Grabiner et al. (53) | ||
| PAR1 | Thrombin | Endothelial cells | Delekta et al. (49) and Klei et al. (56) |
| PAF-R | PAF | Intestinal epithelial cells | Borthakur et al. (48) |
| (C) Receptor tyrosine kinases in solid tumors | |||
| Receptor | Ligand | Tumor-type | Reference |
| EGFR | EGF | Non-small cell lung carcinoma | Li et al. (57) |
| Breast and other cancer cells | Jiang et al. (58) | ||
| HER2 | Breast cancer | Pan et al. (59) | |