Figure 4.

Comparison of the alcohol’s bilayer perturbing potency at pH 7. (A) D, as determined in Fig. 2, is shown as a function of the alcohol’s partition coefficient (K_p). A linear fit (solid line) to the results for all alcohols gives a slope = 0.8, R² = 0.99. Excluding PFTB (red dashed line), the fit gives a slope close to one; slope = 0.96, R² = 0.99. (B) D, as determined in Fig. 2, is shown as a function of the molecular volume of the tested fluoroalcohols and their nonfluorinated counterparts. (C) The mole fractions in the bilayer at D (m_alc) as a function of molecular volume are shown. To see this figure in color, go online.