Table 2.

Changes in Bilayer Partitioning with the Addition of a Methyl or Trifluoromethyl Group

Substitutiona	${\mathit{K}}_{\mathbf{p}}^{\mathit{I}\to \mathit{II}}={\mathit{K}}_{\mathbf{p}}^{\mathit{II}}/{\mathit{K}}_{\mathbf{p}}^{\mathit{I}}$	$\mathit{\Delta \Delta }{\mathit{G}}_{\mathbf{p}}^{\mathit{I}\to \mathit{II}}=\mathit{\Delta \Delta }{\mathit{G}}_{\mathbf{p}}^{\mathit{II}}-\mathit{\Delta \Delta }{\mathit{G}}_{\mathbf{p}}^{\mathit{I}}$ (kJ/mole)
H → CH3	2.3 ± 0.3	2.1 ± 0.3
CH3 → CF3	4.1 ± 0.6	3.5 ± 0.4
H → CF3	10.1 ± 0.9	5.7 ± 0.2

^aSee Table S2 for calculations.