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Liver Enzyme Changes after AAV8.hFVIII Re-administration
Serum alanine transaminase (ALT) (A) and aspartate transaminase (AST) (B) were monitored at different time points post-AAV8/hFVIII re-administration in hemophilia dogs U10 and U11. Normal canine ALT range is 12–118 U/L and AST level is 15–66 U/L, as displayed in the gray area.
