Table 2.

First-line Medications for Cutaneous Tuberculosis.

Medication	Adult Dosing	Children Dosing	Adverse Reactions
Isoniazid	5mg/kg daily, max 300 mg 15 mg/kg TIW	10–15 mg/kg daily 15–20 mg BIW	Elevated liver enzymes, peripheral neuritis, hypersensitivity
Rifampin	10 mg/kg daily, max 600 mg 10 mg/kg TIW, max 600 mg	15–20 mg daily or BIW	Orange discoloration of secretions or urine, staining of contact lenses, hepatitis, thrombocytopenia, pruritus, influenza-like reaction, oral contraceptives may be ineffective
Pyrazinamide	20–25 mg kg daily, max 1600 mg 25–35 mg/kg TIW, max 2400 mg 40–50 mg/kg BIW, max 400 mg	30–40 mg/kg daily 50 mg BIW	Hepatotoxic effects, hyperuricemia, arthralgia, gastrointestinal tract upset, pruritus, rash
Ethambutol	15–20 mg/kg daily, max 1600 mg 25–35 mg/kg TIW, max 2400 mg 40–50 mg/kg BIW, max 4000 mg	15–25 mg/kg daily 50 mg/kg BIW	Optic neuritis, decreased red-green color or discrimination, gastrointestinal tract disturbances, hypersensitivity

TIW = three times a week. BIW = two times a week.