Skip to main content
. 2018 Sep;125(9):1433–1443. doi: 10.1016/j.ophtha.2018.03.040

Table 2.

Comparison of Phenotypic Features between Carriers and Noncarriers of COL8A1 Variants in the Rotterdam Study

Protein Change COL8A1 Variant and Age-Related Macular Degeneration (n = 16) COL8A1 Variant, No Age-Related Macular Degeneration (n = 11) No COL8A1 Variant and Age-Related Macular Degeneration (n = 450)
Age at last visit (yrs) 79.6 (SD, 6.3) 82.5 (SD, 7.9) 80.0 (SD, 6.5)
Spherical equivalent –0.37 (SD, 1.86) 1.14 (SD, 1.83) 1.26 (SD, 2.29)
Mild myopia (–3 to –6 D; %) 3/16 (19) 1/11 (9) 23/437 (5)
Severe myopia (≤ –6 D; %) 0/16 (0) 0/11 (0) 2/437 (0)
Corneal curvature (mm) 7.72 (SD, 0.32) 7.58 (SD, 0.26) 7.70 (SD, 0.26)
IOP (mmHg) 13.8 (SD, 3.0) 14.3 (SD, 2.8) 13.9 (SD, 3.3)
VCDR 0.36 (SD, 0.18) 0.37 (SD, 0.24) 0.32 (SD, 0.18)
Subtype of AMD (no.) 3 GA, 0 CNV, 0 mixed, 13 early 29 GA, 21 CNV, 21 mixed, 379 early
Drusen area >10% (%) 4/16 (25) 0/11 (0) 88/450 (20)
Presence of hyperpigmentation (%) 14/16 (88) 1/11 (9) 287/450 (64)
Presence of reticular drusen (%) 0/16 (0) 0/11 (0) 27/450 (6)
Presence of drusen outside grid (%) 10/16 (63) 7/11 (64) Not available

AMD = age-related macular degeneration; CNV = choroidal neovascularization (wet AMD); D = diopters; GA = geographic atrophy (dry AMD); IOP = intraocular pressure; SD = standard deviation; VCDR = vertical cup-to-disc ratio.

P = 0.005 independent samples t test (2-tailed) between AMD patients carrying a COL8A1 variant (n = 16) and AMD patients without variants in COL8A1 (n = 437), t = 2.81, degrees of freedom, 451.

Geographic atrophy and CNV.