Table 1.
Inhibitory effects of synthesised compounds against S. pneumoniae Nan A.
| Compounds | IC50 (μM) a | Compounds | IC50 (μM) |
|---|---|---|---|
| 4a | 0.6 ± 0.1 | 5i | 1.0 ± 0.5 |
| 4b | 1.0 ± 0.4 | 5j | 0.9 ± 0.3 |
| 4c | 3.4 ± 1.0 | 5k | 1.0 ± 0.1 |
| 4d | 1.5 ± 0.7 | 5l | 1.8 ± 0.2 |
| 4e | 0.4 ± 1.2 | 5m | 1.0 ± 0.2 |
| 4f | 4.7 ± 0.5 | 5n | 1.8 ± 0.4 |
| 5a | 1.5 ± 0.7 | 5o | 1.2 ± 0.1 |
| 5b | 0.6 ± 0.1 | 5p | 0.6 ± 0.2 |
| 5c | 1.0 ± 0.4 | 5q | 1.6 ± 0.1 |
| 5d | 0.7 ± 0.2 | 5r | 1.5 ± 0.2 |
| 5e | 0.2 ± 0.1 | 5s | 1.5 ± 0.1 |
| 5f | 1.5 ± 0.8 | 6 | 82.1 ± 7.6 |
| 5g | 4.4 ± 0.1 | 7 | 2.6 ± 0.6 |
| 5h | 7.1 ± 0.1 | 8 | 6.2 ± 1.5 |
a
IC50 values of compounds represent the concentration that caused 50% enzyme activity loss; all compounds were examined in a set of triplicates experiment.