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. Author manuscript; available in PMC: 2018 Aug 22.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2017 May 16;52(4):414–424. doi: 10.1080/10409238.2017.1325828

Figure 3.

Figure 3

Hematopoietic development during in vitro differentiation. The development process is similar between human cells in vitro and cells in vivo; albeit with a lack of spatial separation in vitro. Hematopoietic stem and progenitor cells (HSPCs) are derived from the mesodermal lineage that is further specified to become cells that will contribute to definitive hematopoiesis. These cells are pushed towards an endothelial fate by a growth factor cocktail usually containing VEGF, and eventually become hemogenic endothelium. The emergence process yields HSPCs expressing various hematopoietic marker genes.