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. Author manuscript; available in PMC: 2019 Jul 18.
Published in final edited form as: ACS Chem Neurosci. 2018 Apr 26;9(7):1572–1581. doi: 10.1021/acschemneuro.8b00126

Figure 2.

Figure 2.

Optimization plan to introduce a cyclic constraint and a chiral center into the ML380 scaffold to afford racemic indanyl analog 7. Enantiospecific activity was noted, with the (R)-enantiomer 8 displaying an improved EC50 of 481 nM, while the (S)-enantiomer 9 was inactive.