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. Author manuscript; available in PMC: 2019 Jul 18.
Published in final edited form as: ACS Chem Neurosci. 2018 Apr 26;9(7):1572–1581. doi: 10.1021/acschemneuro.8b00126

Table 2. Structure and Activities of Analogs 14a.

graphic file with name nihms-984953-t0022.jpg

compd R hM5 EC50 (nM) (pEC50 ± SEM) hM5 % ACh Max
14a H >10000 (<5) <25
14b Me 2535 (5.60 ± 0.03)   70 ± 5
14c n-Pr 112 (7.08 ± 0.27)   73 ± 4
14d n-Bu 349 (6.46 ± 0.02)   77 ± 3
14e CD2CH3 456 (6.36 ± 0.07)   74 ± 3
a

hM5 pEC50, and ACh Max data reported as averages ± SEM from our functional calcium assay; n = 3 determinations.