. Author manuscript; available in PMC: 2019 Jul 18.

Published in final edited form as: ACS Chem Neurosci. 2018 Apr 26;9(7):1572–1581. doi: 10.1021/acschemneuro.8b00126

Table 3. Structure and Activities of Analogs 18^a.

graphic file with name nihms-984953-t0023.jpg

Compound	hM₅ EC₅₀ (nM) (pEC₅₀±SEM)	hM₅ % ACh Max
18a	500 (6.42±0.26)	83±5
18b	5,413 (5.27±0.05)	64±4
18c	2,612 (5.60±0.08)	74±4
18d	2,515 (5.61±0.07)	68±2
18e	631 (6.23±0.08)	77±5
18f	314 (6.53±0.08)	70±6
18g	41 (7.46±0.15)	74±6
18h	58 (7.35±0.13)	72±7
18i	76 (7.20±0.12)	79±6
18j	161 (6.86±0.11)	76±6
18k	298 (6.55±0.09)	69±4

hM₅ pEC₅₀, and ACh Max data reported as averages ± SEM from our functional calcium assay; n = 3 determinations.

Table 3. Structure and Activities of Analogs 18a.