. Author manuscript; available in PMC: 2019 Jul 18.

Published in final edited form as: ACS Chem Neurosci. 2018 Apr 26;9(7):1572–1581. doi: 10.1021/acschemneuro.8b00126

Table 4.

Human and Rat M₅ PAM Activities of Select Analogs 18^a

compd	hM₅ EC₅₀ (nM) (pEC₅₀ ± SEM)	hM₅ % ACh Max	rM₅ EC₅₀ (nM) (pEC₅₀ ± SEM)	rM₅ % ACh Max
18a	500 (6.42 ± 0.26)	83 ± 5	418 (6.40 ± 0.10)	82 ± 4
18g	41 (7.46 ± 0.15)	74 ± 6	74 (7.13 ± 0.04)	76 ± 7
18h	58 (7.35 ± 0.13)	72 ± 7	79 (7.12 ± 0.07)	84 ± 2
18i	76 (7.20 ± 0.12)	79 ± 6	71 (7.19 ± 0.14)	75 ± 8
18j	161 (6.86 ± 0.11)	76 ± 6	196 (6.71 ± 0.02)	81 ± 3

hM_s and rM_s pEC₅₀ and ACh Max data reported as averages ± SEM from our functional calcium assay; n = 3 determinations.