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. Author manuscript; available in PMC: 2019 Jul 26.
Published in final edited form as: J Med Chem. 2018 Jul 13;61(14):6163–6177. doi: 10.1021/acs.jmedchem.8b00583

Figure 5:

Figure 5:

A genome-scale CRISPRi screen determines mechanisms of cellular response to JG-294 in K562 cells with stable expression of dCas9-CRAB. Gene knockdown either promoted or inhibited cell growth in the presence of JG-294 were identified. Each dot is the drug phenotype for a gene. The data is normalized and scaled as previously described.