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. Author manuscript; available in PMC: 2019 Jul 26.
Published in final edited form as: J Med Chem. 2018 Jul 13;61(14):6163–6177. doi: 10.1021/acs.jmedchem.8b00583

Figure 6:

Figure 6:

JG-231 and JG-345 show evidence of Hsp70 target engagement in vivo. MCF-7 xenografts were established in NSG mice treated for 3 days with JG-231, JG-345 or vehicle control. (See text). Tumors were harvested and blotted for Akt and HuR. Results are representative of at least two independent experiments.Quantification of band intensities was performed using ImageJ. ** indicates p < 0.05, *** p < 0.005.