Table 2:
Substituents on the Thiazolium Ring are Important for Bioactivity
 | ||||
|---|---|---|---|---|
| Compd | R3 | MCF-7 IC50/μM |
MDA-MB-231 IC50/μM |
MEF IC50/μM |
| JG-98 |  |
0.71 ± 0.22 | 0.39 ± 0.03 | 4.2 ± 1 |
| 22 |  |
0.19 ± 0.01 | 0.18 ± 0.02 | 0.70 ± 0.03 |
| 33 |  |
0.16 ± 0.01 | 0.16 ± 0.01 | 1.4 ± 0.1 |
| 34 |  |
1.5 ± 0.1 | 1.6 ± 0.2 | 1.7 ± 0.1 |
| 35 |  |
>5 | 7.2 ± 0.8 | > 5 |
| 36 |  |
0.21 ± 0.01 | 0.12 ± 0.02 | 5.5 ± 0.5 |
| 37 |  |
1.5 ± 0.1 | 0.97 ± 0.10 | 2.0 ± 0.2 |
| 38 |  |
0.81 ± 0.09 | 0.13 ± 0.01 | 2.7 ± 0.1 |
| 39 |  |
0.73 ± 0.06 | 0.11 ± 0.01 | 4.4 ± 0.3 |
| 40 |  |
0.16 ± 0.02 | 0.22 ± 0.02 | 3.2 ± 0.3 |
| 41 |  |
0.52 ± 0.09 | 0.20 ± 0.02 | 1.3 ± 0.1 |
| 42(JG-231) |  |
0.12 ± 0.01 | 0.25 ± 0.02 | 2.5 ± 0.1 |
| 43 |  |
0.098 ± 0.008 | 0.080 ± 0.008 | 4.2 ± 0.4 |
| 44 |  |
0.96 ± 0.08 | 0.74 ± 0.07 | 4.9 ± 0.3 |
| 45 |  |
>5 | 2.3 ± 0.3 | 8.9 ± 0.8 |
| 46 |  |
>5 | >20 | 4.2 ± 0.6 |
| 47 |  |
>5 | 10 ± 2 | 7.6 ± 0.3 |