. Author manuscript; available in PMC: 2019 Jul 26.

Published in final edited form as: J Med Chem. 2018 Jul 13;61(14):6163–6177. doi: 10.1021/acs.jmedchem.8b00583

Table 4:

Selectivity Index, Solubility and Microsomal Stability of Selected Compounds

Compd	Selectivity Index (MEF/MCF7)	Selectivity Index (IMR-90/MCF7)	Solubility (uM)	Microsomal Stability (T_1/2, min)
JG-98	6	2	31	37
9(JG-194)	11	11	16	40
31	12	7	31	>60
42 (JG-231)	20	38	16	>60
43	42	45	<8	25
49	11	10	8	53
51	10	14	<8	>60
53	13	27	<8	27
55	10	18	8	13
56	13	29	31	21
57 (JG-345)	20	65	31	25
58	6	7	31	33
60 (JG-294)	35	98	31	>60
61	12	30	16	37