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. Author manuscript; available in PMC: 2019 Jul 26.
Published in final edited form as: J Med Chem. 2018 Jul 13;61(14):6163–6177. doi: 10.1021/acs.jmedchem.8b00583

Table 5:

Pharmacokinetics of JG-98 analogs

Pharmacokinetics Parameters JG-98* JG-194 JG-231 JG-294 JG-345
Cmax / nM 73 64 159 58 87
Tmax / h 1 2 2 1 1
t1/2 / h 23 >24 21.6 >24 11.4
AUC0 - ∞/ nM ×h 1667 5074 3401 2429 1524
*

3mg/kg; from Li et al. 2015 Mol. Cancer Ther. 14:642–648.