Table 3.

Association of early age-related macular degeneration with SNPs

Gene	SNP	1 vs 0 copy of minor allele			2 vs 0 copies of minor allele			Additive per allele
		OR*	95% CI	P	OR*	95% CI	P	OR*	95% CI	P
TLR3	rs3775291	1.01	0.86 to 1.20	0.868	1.13	0.83 to 1.54	0.425	1.04	0.92 to 1.16	0.520
LOC107986598	rs4711751	0.95	0.78 to 1.14	0.558	0.91	0.69 to 1.20	0.502	0.95	0.84 to 1.08	0.452
FRK	rs1999930	0.83	0.66 to 1.05	0.117	1.63	0.39 to 6.77	0.498	0.88	0.69 to 1.12	0.285
ABCA1	rs1883025	0.96	0.79 to 1.17	0.698	0.96	0.77 to 1.19	0.726	0.98	0.88 to 1.09	0.699
LIPC	rs10468017	0.97	0.82 to 1.14	0.677	1.08	0.67 to 1.75	0.744	0.99	0.85 to 1.15	0.913
CETP	rs3764261	1.08	0.91 to 1.28	0.365	1.10	0.90 to 1.33	0.339	1.06	0.96 to 1.17	0.228
APOE	rs429358	0.93	0.77 to 1.12	0.454	0.80	0.35 to 1.84	0.594	0.93	0.77 to 1.10	0.380
APOE	rs7412	0.97	0.74 to 1.27	0.826	1.38	0.42 to 4.55	0.594	1.00	0.79 to 1.27	0.994
CFD	rs3826945	1.02	0.88 to 1.20	0.758	1.10	0.87 to 1.39	0.399	1.04	0.94 to 1.15	0.416

*Adjusted for age, sex and centre.

SNP, single nucleotide polymorphism.