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. 2018 May 31;77(9):1362–1371. doi: 10.1136/annrheumdis-2018-213031

Figure 2.

Figure 2

Genes differentially expressed by SSc dermal fibroblasts collected at baseline compared with normal dermal fibroblasts represent a typical profibrotic signature dominated by genes regulated by TGFβ. Gene expression of normal, SSc PBO and SSc TCZ dermal fibroblasts collected at baseline and normalised to the average NF expression. Protein coding RNA showing a median RPKM ≥1, 1.5-fold overexpressed or underexpressed compared with NF, with an adjusted p≤0.05, was selected as significantly differentially expressed (n=578). Genes and samples were clustered using the Ward method. BL, baseline; NFs, normal fibroblasts; PBO, placebo; RPKM, reads per kilobase of transcript per million mapped reads; SSc, systemic sclerosis; TCZ, tocilizumab; TGFβ, transforming growth factor beta.