Table 1. Genetic associations of fecal metabolites.
Three metabolites and one metabolite ratio significantly associated with genetic loci in the discovery cohort (n=739). We report their respective heritabilities (H2), the associated variant along with its chromosomal position and the nearest gene, and the effect (± its standard error). P-values in the discovery and replication cohorts were calculated using the two-sided score test implemented in GEMMA and combined using fixed-effects inverse variance meta-analysis. The p-gain describes the strength of the association of the metabolite ratio relative to the associations of each individual metabolite.
| Discovery | Replication | Meta-Analysis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Metabolite | H2 | MAF | SNP | Gene | Effect | P | p-gain | Effect | P | Effect | P |
| 1,3-dimethylurate/ 5-acetylamino-6-amino-3-methyluracil |
40.2% | 24.7% | rs35246381 (8:1841502) |
NAT2 | -0.17±0.02 | 7.0×10-21 | 7.5×109 | -0.22±0.03 | 3.5×10-10 | -0.18±0.01 | 3.3×10-36 |
| 3-hydroxyhexanoate | 20.7% | 3.7% | rs62311177 (4:92962004) |
GRID2 | 0.41±0.06 | 2.9×10-12 | 0.07±0.09 | 0.429 | 0.32±0.05 | 3.0×10-11 | |
| eicosapentaenoate (EPA; 20:5n3) | 16.1% | 1.4% | rs149572251 (20:34322936) |
ITCH | 1.45±0.21 | 3.4×10-11 | -0.23±0.38 | 0.544 | 1.06±0.18 | 6.8×10-9 | |
| 3-phenylpropionate (hydrocinnamate) | 23.9% | 1.6% | rs58539483 (11:28830501) |
AC090833.1 | -1.31±0.19 | 3.6×10-11 | -0.39±0.22 | 0.076 | -0.92±0.14 | 1.5×10-10 | |