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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Rheumatology (Oxford). 2018 Apr 1;57(4):748–755. doi: 10.1093/rheumatology/kex447

Figure 3. Histological analysis of untreated paws with collagen-induced arthritis at different time points.

Figure 3

A, B. Left foreleg of a mouse 24 h post onset of clinical signs (score 3). R - radial bone; arrowhead: accumulation of degenerate neutrophils, arrow: epidermis. C-F. Left foreleg of a mouse 5 days post onset of clinical signs (score 4). R - radius, * - joint space. E. Neutrophils in the infiltrate are found to express NETs (arrowheads). F. Macrophages can be seen in moderate numbers (arrows). A, C: HE stain; B, D-F: HRP (Iba-1, histone H3) and ABC (Ly6G) method, hemalaun counterstain. Bars = 200 μm (A), 100 μm (B, D-F). 2.5 mm (C).