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. 2018 Aug 13;131(15):jcs216382. doi: 10.1242/jcs.216382

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© 2018. Published by The Company of Biologists Ltd

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Fig. 5. — β1 integrin subunits mediate glioma cell migration on laminin 511 and invasion in 3D astrocyte scaffolds. (A) Migration of U-251 and E-98 cells, transfected with non-targeting control (NT) siRNAs or anti-β1-integrin siRNAs, from spheroids on laminin-511-coated culture surface (24 h) and the cell invasion in 3D astrocyte scaffolds (48 h), in medium with isotypic IgG1 and control cRADfV peptide or adhesion-perturbing anti-β1-integrin 4B4 mAb combined with cRGDfV peptide. (B) Average migration distance of U-251 and E-98 cells on plastic surface coated with laminin 511 and invasion in 3D astrocyte scaffolds. Data represent 15-16 (U-251) or 15-18 (E-98) spheroids per condition in astrocyte scaffolds, and 16-32 (U-251) or 15-24 (E-98) spheroids per condition on laminin 511 from three independent siRNA transfections. Values display the median (black line), 25th and 75th percentiles (boxes), and maximum and minimum (whiskers). P-values shown were obtained using the Mann-Whitney test. n.s., not significant. Scale bars: 100 µm.