Table 4. Factors associated with mortality in adults according to drug resistant tuberculosis type in Eastern Cape, South Africa; 2011 to 2013.
| DR-TB Characteristic | MDR-TB | XDR-TB | ||
|---|---|---|---|---|
| aIRR (95% CI) | P-value a | aIRR (95% CI) | P-value a | |
| HIV ART Status | ||||
| Negative | Ref | |||
| Co-infected on ART | 1.5 (1.4–1.7) | <0.001 | 1.1 (1.0–1.3) | 0.062 |
| Co-infected not on ART | 3.9 (3.3–4.6) | <0.001 | 1.8 (1.5–2.2) | <0.001 |
| Status unknown | 1.2 (0.8–1.7) | 0.488 | 1.1 (0.7–1.7) | 0.709 |
| Age | ||||
| 18–29 | Ref | Ref | ||
| 30–44 | 1.2 (1.1–1.3) | 0.034 | 1.0 (0.8–1.1) | 0.671 |
| 45–59 | 1.2 (1.0–1.3) | 0.058 | 1.1 (0.9–1.2) | 0.825 |
| 60 + | 1.9 (1.6–2.3) | <0.001 | 1.3 (0.9–1.7) | 0.179 |
| Treatment Initiation Site | ||||
| Community | Ref | Ref | ||
| DR-TB Hospital | 1.7 (1.5–1.9) | <0.001 | 1.5 (1.3–1.8) | <0.001 |
| Previous Drug History | ||||
| New | Ref | Ref | ||
| History of 1st line drugs | 1.2 (1.1–1.3) | 0.001 | 1.0 (0.9–1.2) | 0.734 |
| History of 2nd line drugs | 1.4 (1.2–1.6) | 0.001 | 1.3 (1.1–1.5) | 0.018 |
| Registration Year | ||||
| 2011 | Ref | Ref | ||
| 2012 | 1.0 (0.8–1.1) | 0.893 | 1.1 (1.0–1.3) | 0.072 |
| 2013 | 1.2 (1.1–1.4) | 0.028 | 1.1 (1.0–1.3) | 0.119 |
MDR-TB, multi drug resistant tuberculosis; XDR-TB, extensively drug resistant TB; HIV, Human Immunodeficiency Virus; ART, Anti-retroviral therapy; aIRR adjusted incidence risk ratios,
a P-value calculated using modified Poisson regression.