Table 1. LD50a of spores.
A/J mice | C57BL/6 mice | |||
---|---|---|---|---|
Strain | s.c. | i.n. | s.c. | i.n. |
G9241b | 7 | 3 x 103 | 44 (16–100) |
4 x 105 (2 x 105–9 x 105) |
ΔhasACB | 44c (11–116) |
2 x 104c (7 x 103–5 x 104) |
6 x 103c (2 x 103–2 x 104) |
3 x 106c (8 x 105–2 x 107) |
ΔwchA | 8 (1–30) |
3 x 103 (1 x 103–7 x 103) |
5 x 102c (2 x 102–1 x 103) |
4 x 105 (1 x 105–1 x 106) |
ΔwchAΔhasACB | 8 x 103c (3 x 103–3 x 104) |
>107 | >107 | N/A |
a All LD50 values calculated by probit analysis; 95% confidence interval, if provided by SPSS software, in parentheses
b As previously published [12]
c LD50 significantly different from G9241 as determined by comparison of relative median potencies in SPSS software