Table 1.
Characteristics of older women with and without SSRI treatment
| SSRI No (n = 971) | SSRI Yes (n = 86) | p | |
|---|---|---|---|
| Age (years) | 77.7 ± 1.5 | 77.9 ± 1.6 | 0.38 |
| Height (cm) | 161.9 ± 5.81 | 162.5 ± 5.79 | 0.34 |
| Weight (kg) | 68.4 ± 12.0 | 69.7 ± 11.7 | 0.37 |
| Appendicular lean mass index (kg/m2) | 6.58 ± 0.89 | 6.51 ± 0.80 | 0.52 |
| Fat mass (kg) | 26.9 ± 7.49 | 27.4 ± 7.29 | 0.52 |
| Age at menopause (years) | 49.8 ± 4.85 | 50.2 ± 4.09 | 0.46 |
| Physical activity score (PASE) | 109 ± 52.9 | 92.9 ± 52.0 | 0.01 |
| Calcium intake (mg/day) | 704 ± 392 | 733 ± 411 | 0.53 |
| MCS | 54.8 ± 8.32 | 48.8 ± 11.3 | < 0.001 |
| PCS | 45.6 ± 10.8 | 42.0 ± 10.9 | 0.003 |
| Fall accident last year, % (n) | 30.2 (293) | 39.5 (34) | 0.07 |
| Fracture, % (n) | 4.8 (47) | 3.5 (3) | 0.57 |
| Head injury, % (n) | 6.7 (65) | 10.5 (9) | 0.19 |
| Sprain, % (n) | 2.8 (27) | 3.5 (3) | 0.71 |
| Bruise, % (n) | 12.9 (125) | 24.4 (21) | 0.003 |
| Hyperthyroidism, % (n) | 6.2 (60) | 7.0 (6) | 0.78 |
| Hypothyroidism, % (n) | 13.6 (131) | 10.5 (9) | 0.42 |
| Diabetes, % (n) | 9.2 (89) | 11.6 (10) | 0.46 |
| Glucocorticoids p.o., % (n) | 2.9 (28) | 1.2 (1) | 0.51a |
| Parkinson’s disease, % (n) | 0.6 (6) | 1.2 (1) | 0.45a |
| Rheumatoid arthritis, % (n) | 3.6 (35) | 2.3 (2) | 0.54 |
| Prior stroke, % (n) | 7.7 (75) | 15.1 (13) | 0.02 |
| Current smoking, % (n) | 5.3 (51) | 5.8 (5) | 0.82 |
| Previous fracture, % (n) | 37.5 (364) | 37.2 (32) | 0.96 |
| Vertebral fracture, % (n) | 4.8 (46) | 5.9 (5) | 0.64 |
| Peripheral fracture, % (n) | 24.3 (235) | 25.9 (22) | 0.75 |
| Heredity of hip fracture, % (n) | 14.7 (143) | 18.6 (16) | 0.34 |
| High alcohol intake, % (n) | 0.2 (2) | 2.3 (2) | < 0.04a |
| Chronic liver disease, % (n) | 0.4 (4) | 1.2 (1) | 0.34a |
| Celiac disease, % (n) | 1.2 (12) | 1.2 (1) | 1.00a |
Statistically significant values (p < 0.05) are given in bold
An independent samples t test was used to compare differences in continuous variables between SSRI-users and non-users. Proportions for dichotomous variables were compared by chi-square test or Fisher’s exact test for small sample sizes. High alcohol intake was defined as more than three standard drinks per day
SSRI selective serotonin reuptake inhibitors, MCS mental health component scale, PCS physical health component scale. Previous fracture = fracture after the age of 50
aFisher’s exact test