Figure 7. Evoked Firing.

Trains of action potential spikelets in LNs in response to depolarizing current step as shown. In current clamp, one can study the evoked firing properties of neurons, including spikelet amplitude, and spikelet frequency as a function of stimulus strength. This wild-type neuron fired 18 spikelets in response to a 30 pA stimulus. Higher or lower spikelet frequency in mutant neurons compared to frequency in control cells indicates hyper- or hypoexcitability, respectively. The amplitude peaks are smaller than those seen in other organisms as we are recording from the inexcitable cell soma and action potentials are generated on the distant processes.