Table 2.

Results of single SNP association analyses.

BRCA1 SNPs	NHW					Hispanic
	All (n=499)		Multiplex (n=151)		Simplex (n=348)	All (n=308)		Multiplex (n=92)		Simplex (n=216)
	FBAT	FBAT-e	FBAT	FBAT-e	FBAT	FBAT	FBAT-e	FBAT	FBAT-e	FBAT
rs799906	0.64	0.65	0.64	0.67	0.32	0.56	0.57	0.09	0.10	0.54
rs799917	0.68	0.70	0.64	0.67	0.38	0.99	0.99	0.18	0.17	0.24
rs16941	0.62	0.64	0.77	0.79	0.38	0.12	0.09	0.04	0.02	0.73
rs8176194	0.62	0.62	0.26	0.27	0.76	0.26	0.24	0.08	0.06	1.00
rs8070179	0.54	0.54	0.82	0.83	0.53	0.35	0.35	0.05	0.06	0.73
rs8176318	0.68	0.69	0.45	0.49	0.26	0.05	0.04	0.07	0.08	0.27
BRCA2 SNPs	NHW					Hispanic
	All (n=499)		Multiplex (n=151)		Simplex (n=348)	All (n=308)		Multiplex (n=92)		Simplex (n=216)
	FBAT	FBAT-e	FBAT	FBAT-e	FBAT	FBAT	FBAT-e	FBAT	FBAT-e	FBAT
rs206115	0.11	0.13	0.01	0.02	0.94	0.15	0.15	0.01	0.02	0.51
rs144848	0.42	0.44	0.21	0.24	0.05	0.89	0.88	0.21	0.24	0.92
rs206079	0.29	0.32	0.10	0.15	0.94	0.42	0.42	0.10	0.15	0.48
rs9943888	0.78	0.78	0.53	0.52	0.38	0.91	0.91	0.53	0.52	0.97
rs9534342	0.54	0.54	0.05	0.06	0.50	0.60	0.60	0.05	0.06	0.85
rs11571836	0.79	0.80	0.31	0.34	0.21	0.55	0.55	0.31	0.36	0.53

FBAT, Family Based Association Test; FBAT –e, extended pedigree option

NHW, nonHispanic white

All = all families combined (multiplex + simplex)

Significant if P≤0.004.