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Individual base model estimated tacrolimus apparent clearance values (CL/F, symbols) and mean values (black lines) stratified by CYP3A5*3*6*7 metabolic composite. Poor metabolizers (CPMCYP3A5) exhibit lower CL/F (mean 19.8 L.hr−1), compared to intermediate CIMCYP3A5 (mean 29.5 L.hr−1) and extensive CEMCYP3A5 metabolizers (mean 45.0 L.hr−1). Open-circles represent white patients and closed-circles represent African-American patients.
