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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: J Clin Pharmacol. 2018 May 18;58(9):1184–1195. doi: 10.1002/jcph.1118

Figure 6.

Figure 6

Boxplots of model-simulated tacrolimus AUCss,0–12hr a) and 12-hour trough concentrations b) stratified by CYP3A5*3*6*7 metabolic composite, obtained with different dosing regimens (i.e., Dose i = 0.075 mg/kg/day given as 0.0375 mg/kg every 12 hours, dose i x1.5, and x2).20 The dashed lines represent the targeted therapeutic ranges: between 120 and 200 hr.ng/mL for AUCss,0–12hr, and between 5 and 12 ng/mL for 12-hour trough concentrations.28 Percentages of patients exhibited AUCss,0–12hr and trough concentrations above, within and below the therapeutic range are indicated in each graph.