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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Arthritis Rheumatol. 2018 Jun 28;70(8):1319–1330. doi: 10.1002/art.40498

Figure 2. Variants of the IL1RN locus are associated with sJIA in the INCHARGE case-control collection.

Figure 2

SNP associations within the IL1RN locus are shown, colored by pairwise linkage disequilibrium (LD) with the most strongly associated SNP, rs55663133 (A). The brown horizontal line demonstrates the study-wide significance threshold. In Panel B, a forest plot demonstrates the effect size of rs55663133 by meta-analysis and in individual study populations. Panel C displays pairwise LD with the peak sJIA-associated SNP, rs55663133 (star) in the U.S. case-control population. The top 7 sJIA associated markers (19–25) form a strong LD block.