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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Arthritis Rheumatol. 2018 Jun 28;70(8):1319–1330. doi: 10.1002/art.40498

Table 3.

Association between sJIA-associated quantitative trait loci for IL1RN expression (and serum levels of IL-1RA protein) and response to anakinra therapy in 38 patients from the INCHARGE U.S. population.

Homozygote frequency
SNP Effect allele
(high expression)		 Non-responder
(n=9)		 Any responder
(n=29)		 P value OR (95CI)
rs55663133 - 0.67 0.22 1.6 × 10−2 7.0 (1.3, 36.7)
rs62158854 T 0.67 0.22 1.6 × 10−2 7.0 (1.3, 36.7)
rs62158853 C 0.67 0.24 2.1 × 10−2 6.3 (1.2, 32)
rs55709272 T 0.67 0.1 9.8 × 10−4 17.3 (2.8, 108.1)
rs7580634 G 0.67 0.1 9.8 × 10−4 17.3 (2.8, 108.1)
rs4251961 T 0.78 0.21 1.8 × 10−3 13.4 (2.2, 82)
rs555447483 - 0.71 0.08 7.7 × 10−4 28.7 (3.2, 255.8)

SNP, single nucleotide polymorphism; OR, odds ratio; 95CI, 95% confidence interval.