Skip to main content
. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Gynecol Oncol. 2018 May 22;150(1):127–135. doi: 10.1016/j.ygyno.2018.05.008

Figure 2. Recurrent non-synonymous somatic genetic alterations detected by massively parallel sequencing in primary mucinous ovarian cancers.

Figure 2

(A) Recurrent (n≥2) non-synonymous somatic mutations (top) and amplifications and homozygous deletions of interest (bottom) identified in 24 tumors initially diagnosed as primary mucinous ovarian cancer in 341 cancer-related genes. Mutation types, gene copy number alterations and sequencing type are color-coded according to the legend. Loss of heterozygosity of the wild-type allele in association with a somatic mutation is depicted by a diagonal bar. EDM, exonuclease domain; Indel, small insertion/deletion; Seq, sequencing; SNV, single nucleotide variant. (B) Cancer cell fractions of non-synonymous somatic mutations as defined by ABSOLUTE [27] in tumors initially diagnosed as primary mucinous ovarian cancer. Cancer cell fractions and sequencing type are color-coded according to the legend, and clonal mutations are depicted by an orange box. Loss of heterozygosity of the wild-type allele in association with a somatic mutation is depicted by a diagonal bar. Seq, sequencing.