Table 1.
| a: Baseline characteristics according to tertiles of waist circumference in the combined population | ||||
|---|---|---|---|---|
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| (MALES + FEMALES) | ||||
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| Tertile | 1 | 2 | 3 | P-value |
| N | 2797 | 2789 | 2674 | |
| Waist circumference, cm | 74.5 (5.3) | 88.5 (3.5) | 103.4 (7.6) | <0.001 |
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| NT-proBNP, pg/mL | 42.8 (23.3,75.4) | 31.3 (13.9, 66.3) | 35.5 (14.0, 78.3) | <0.001 |
| Sex (Female), N (%) | 2185 (78.1%) | 1173 (42.1%) | 782 (29.2%) | <0.001 |
| Age, years | 43.5 (10.8) | 49.5 (12.6) | 55.1 (11.8) | <0.001 |
| Smoking (last 1 year), N(%) | 1203 (43.1%) | 1037 (37.3%) | 888 (33.3%) | <0.001 |
| Hypertension, N (%) | 292 (10.4%) | 734 (26.3%) | 1227 (46.9%) | <0.001 |
| Diabetes Mellitus, N (%) | 26 (1.0%) | 73 (2.7%) | 213 (8.2%) | <0.001 |
| Hypercholesterolaemia, N (%) | 450 (16.3%) | 803 (29.2%) | 926 (35.1%) | <0.001 |
| Myocardial Infarction, N (%) | 103 (3.7%) | 145 (5.3%) | 244 (9.3%) | <0.001 |
| Body-mass index, kg/m2 | 22.8 (2.4) | 25.8 (2.5) | 29.9 (4.0) | <0.001 |
| Weight, kg | 65.8 (8.0) | 77.9 (8.0) | 91.7 (12.4) | <0.001 |
| Total cholesterol, mmol/L | 5.2 (4.6, 5.9) | 5.7 (4.9, 6.4) | 5.9 (5.2, 6.5) | <0.001 |
| HDL, mmol/L | 1.5 (1.3, 1.8) | 1.2 (1.0, 1.5) | 1.1 (0.9, 1.3) | <0.001 |
| Systolic BP, mm Hg | 118.2 (16.6) | 130.4 (18.7) | 139.1 (19.4) | <0.001 |
| Glucose, mmol/L | 4.4 (4.1, 4.8) | 4.7 (4.4, 5.1) | 5.0 (4.6, 5.6) | <0.001 |
| Insulin resistance (HOMA IR) | 1.2 (0.9, 1.6) | 1.7 (1.2, 2.4) | 2.7 (1.8, 4.2) | <0.001 |
| hs-CRP, mg/L | 0.7 (0.3, 1.9) | 1.2 (0.6, 2.7) | 2.2 (1.1, 4.5) | <0.001 |
| eGFR (mL/min/1.73m2) | 100.6 (15.1) | 94.8 (17.1) | 89.3 (17.7) | <0.001 |
| b: Baseline characteristics according to tertiles of waist circumference in males and females | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Characteristic | MALES | FEMALES | ||||||
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| Tertile | 1 | 2 | 3 | P-value | 1 | 2 | 3 | P-value |
| N | 1437 | 1354 | 1329 | 1406 | 1362 | 1372 | ||
| Waist circumference, cm | 82.4 (5.2) | 93.7 (2.5) | 106.4 (6.8) | <0.001 | 70.6 (3.9) | 81.7 (3.2) | 98.0 (8.8) | <0.001 |
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| NTproBNP, pg/mL | 19.1 (9.1, 38.6) | 26.3 (9.8, 62.2) | 29.7 (11.1, 70.7) | <0.001 | 51.0 (30.1, 86.2) | 48.7 (28.6, 81.6) | 51.7 (26.9, 95.6) | 0.35 |
| Age, years | 44.1 (11.6) | 51.7 (12.8) | 55.8 (11.5) | <0.001 | 42.4 (10.1) | 48.2 (11.7) | 54.1 (12.1) | <0.001 |
| Smoking (last 1 year), N(%) | 624 (43.5%) | 503 (37.3%) | 439 (33.2%) | <0.001 | 626 (44.7%) | 501 (36.9%) | 435 (31.8%) | <0.001 |
| Hypertension, N (%) | 206 (14.3%) | 461 (34.0%) | 693 (52.2%) | <0.001 | 120 (8.5%) | 257 (18.9%) | 516 (37.6%) | <0.001 |
| Diabetes mellitus, N (%) | 24 (1.8%) | 44 (3.4%) | 111 (8.7%) | <0.001 | 7 (0.5%) | 22 (1.7%) | 104 (7.7%) | <0.001 |
| Hypercholesterolaemia, N (%) | 254 (17.9%) | 404 (30.2%) | 455 (35.8%) | <0.001 | 205 (14.7%) | 356 (26.4%) | 505 (37.4%) | <0.001 |
| Myocardial Infarction, N (%) | 72 (5.1%) | 116 (8.7%) | 130 (10.0%) | <0.001 | 42 (3.0%) | 54 (4.1%) | 78 (5.8%) | <0.001 |
| Body-mass index, kg/m2 | 23.2 (2.1) | 26.1 (1.9) | 29.9 (3.1) | <0.001 | 22.0 (2.0) | 25.4 (2.4) | 30.5 (4.6) | <0.001 |
| Weight, kg | 74.4 (8.0) | 83.7 (7.4) | 96.1 (11.6) | <0.001 | 61.9 (6.8) | 70.7 (7.2) | 83.8 (12.8) | <0.001 |
| Total cholesterol, mmol/L | 5.3 (4.7, 6.1) | 5.7 (5.0, 6.4) | 5.8 (5.3, 6.5) | <0.001 | 5.1 (4.5, 5.8) | 5.6 (4.8, 6.4) | 5.9 (5.2, 6.6) | <0.001 |
| HDL, mmol/L | 1.2 (1.0, 1.5) | 1.1 (0.9, 1.3) | 1.0 (0.9, 1.2) | <0.001 | 1.6 (1.4, 1.9) | 1.5 (1.2, 1.7) | 1.3 (1.1, 1.5) | <0.001 |
| Systolic BP, mm Hg | 125.6 (15.2) | 134.2 (17.8) | 142.0 (18.7) | <0.001 | 115.0 (16.0) | 123.7 (19.6) | 134.6 (21.9) | <0.001 |
| Glucose, mmol/L | 4.6 (4.3, 5.0) | 4.8 (4.5, 5.2) | 5.1 (4.7, 5.6) | <0.001 | 4.4 (4.0, 4.7) | 4.6 (4.2, 4.9) | 4.9 (4.5, 5.5) | <0.001 |
| Insulin resistance (HOMA IR) | 1.2 (0.9, 1.8) | 1.8 (1.3, 2.6) | 3.0 (1.9, 4.4) | <0.001 | 1.1 (0.8, 1.5) | 1.5 (1.1, 2.1) | 2.5 (1.7, 4.0) | <0.001 |
| hs-CRP, mg/L | 0.7 (0.3, 1.6) | 1.2 (0.6, 2.7) | 2.0 (1.1, 3.9) | <0.001 | 0.7 (0.3, 1.7) | 1.2 (0.6, 2.9) | 2.6 (1.3, 5.2) | <0.001 |
| eGFR (mL/min/1.73m2) | 100.8 (15.5) | 93.0 (17.4) | 88.8 (17.8) | <0.001 | 101.1 (14.3) | 96.5 (16.3) | 89.3 (17.9) | <0.001 |
NT-proBNP, N-terminal pro-B-type natriuretic peptide; HDL, high-density lipoprotein; BP, blood pressure; hs-CRP, high-sensitive C-reactive protein; eGFR, estimated glomerular filtration rate