Table 2.

a: Associations of NT-proBNP with age, sex and obesity parameters (combined population)
	Univariable			Model 1a			Model 2b
	Std β	R2	p-value	Std β	R2	p-value	Std β	R2	p-value
Age	0.361	0.130	<0.001	-	-	-	-	-	-
Female Sex	0.286	0.082	<0.001	0.320	0.231	<0.001	0.337	0.285	<0.001

b: Sex-stratified associations of NTproBNP with obesity parameters
			Model 1a				Interaction p-value			Model 2b				Interaction p-value
	Males			Females				Males			Females
	Std β	R2	p-value	Std β	R2	p-value		Std β	R2	p-value	Std β	R2	p-value
Waist circumference (SD)	−0.072	0.274	<0.001	−0.129	0.074	<0.001	<0.001	−0.074	0.341	<0.001	−0.166	0.120	<0.001	<0.001
Body-mass index (SD)	−0.084	0.277	<0.001	−0.129	0.075	<0.001	0.001	−0.083	0.342	<0.001	−0.171	0.122	<0.001	0.001
Weight (SD)	−0.056	0.273	<0.001	−0.088	0.067	<0.001	0.040	−0.048	0.339	0.002	−0.117	0.112	<0.001	0.022

SD – standard deviation; R² – adjusted R-squared

^aAge-adjusted associations

^bAssociations after adjusting for age, history of myocardial infarction, hypertension, antihypertensive medication, insulin resistance (HOMA IR), glomerular filtration rate and high-sensitive C-reactive protein