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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: J Neurovirol. 2018 Mar 28;24(4):398–410. doi: 10.1007/s13365-018-0629-1

Figure 1. Combination of HIV infection and MPTP intoxication does not affect neurodegeneration in humanized mice.

Figure 1

A. Representative images of the substantia nigra (SN) and striatum (STR) of humanized NOD/scid-IL-2Rγc null mice treated with MPTP alone or inoculated with HIV for 3 weeks or 4 weeks followed by MPTP intoxication. B. Total numbers of surviving dopaminergic neurons (TH+Nissl+) and non-dopaminergic neurons (TH-Nissl+) in the SN following MPTP intoxication, or HIV infection followed by MPTP intoxication. Percentages of spared dopaminergic neurons are displayed on the representative bar for each treatment. C. Relative TH+ density within striatal termini of dopaminergic neurons. Differences in means (± SEM, n = 3-6) were determined where P < 0.05 compared to PBS (a).